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Assays, reagents, kits, and other assorted products used to detect cellular apoptosis, determine the activity levels of caspase or cathepsin, or identify similar cellular activity.
Contains apoptotic program characterized by certain morphologic features, including loss of plasma membrane asymmetry and attachment, condensation of the cytoplasm and nucleus, and internucleosomal cleavage of DNA
Cells with active caspases can be detected. BD Pharmingen™ Blue Live Cell Caspase Probe contains a fluorochrome-labeled caspase inhibitor. Fluorochrome-labeled caspase inhibitors have three functional domains: fluorochrome , 3-amino acid sequence (VAD) that binds to the active site of the activated caspase, and fluoromethyl ketone (FMK) moiety that allows the probe to irreversibly bind the active caspase.
Cells with active caspases can be detected. BD Pharmingen™ Violet Live Cell Caspase Probe contains a fluorochrome-labeled caspase inhibitor. Fluorochrome-labeled caspase inhibitors have three functional domains: fluorochrome , 3-amino acid sequence (VAD) that binds to the active site of the activated caspase, and fluoromethyl ketone (FMK) moiety that allows the probe to irreversibly bind the active caspase.